울산대학교 | 생명과학부

11월 22일 연사초청세미나 안내
작성자	박**	작성일	2019-11-05	조회수	96
초청세미나 안내 CRISPR/Cas9에 의한 게놈편집에 관심있는 학부생/대학원생들의 많은 참석바랍니다. 1.일시 : 11.22(금) 16시30분 2.장소 : 19호관 417호 3.연사 : 고려대학교 김경미교수 4.발표 주제 : CRISPR/Cas9에 의한 게놈편집 Point mutations caused by nucleobase deamination are a major source of human genetic disorders and diversity. Unlike mutagens causing random nucleobase deamination, RNA-programmable deaminase systems, composed of a catalytically impaired CRISPR?Cas9 variant (D10A Cas9 nickase (nCas9) or catalytically deficient D10A/H840A Cas9 (dCas9) from S. pyogenes) and a deaminase protein from various sources, enable single-nucleotide conversions or base editing in cells and organisms in a guide RNA-dependent manner. These base editing systems can be divided into two categories: cytosine base editors (CBEs) that convert a C:G base pair to a T:A pair and Adenine base editors (ABEs) that convert a A:T pair to a G:C pair. Here we demonstrated the application of this technology in mouse embryos and adult mice.

목록보기